Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that eliminates aberrant mRNAs containing premature termination codons (PTCs). NMD inhibits the production of aberrant proteins that still retain, at least in part, wild-type function as well as dominant-negative peptides. Therefor...

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Main Authors: Usuki, Fusako, Yamashita, Akio, Shiraishi, Tadafumi, Shiga, Atsushi, Onodera, Osamu, Higuchi, Itsuro, Ohno, Shigeo
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773753/
https://ncbi.nlm.nih.gov/pubmed/23983263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300654110
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