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Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that eliminates aberrant mRNAs containing premature termination codons (PTCs). NMD inhibits the production of aberrant proteins that still retain, at least in part, wild-type function as well as dominant-negative peptides. Therefor...

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Bibliografiske detaljer
Main Authors: Usuki, Fusako, Yamashita, Akio, Shiraishi, Tadafumi, Shiga, Atsushi, Onodera, Osamu, Higuchi, Itsuro, Ohno, Shigeo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773753/
https://ncbi.nlm.nih.gov/pubmed/23983263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300654110
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