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Environmental stresses suppress nonsense-mediated mRNA decay (NMD) and affect cells by stabilizing NMD-targeted gene expression

Nonsense-mediated mRNA decay (NMD) is a cellular mechanism that eliminates mRNAs that harbor premature translation termination codons (PTCs). Here, we investigated the effects of environmental stresses (oxidative stress and endoplasmic reticulum (ER) stress) on NMD activity. Methylmercury (MeHg) was...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Usuki, Fusako, Yamashita, Akio, Fujimura, Masatake
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362056/
https://ncbi.nlm.nih.gov/pubmed/30718659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38015-2
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