SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that detects and degrades mRNAs containing premature translation termination codons (PTCs). SMG-1 and Upf1 transiently form a surveillance complex termed “SURF” that includes eRF1 and eRF3 on post-spliced mRNAs during recognition of PTC....

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Autori principali: Yamashita, Akio, Izumi, Natsuko, Kashima, Isao, Ohnishi, Tetsuo, Saari, Bonnie, Katsuhata, Yukiko, Muramatsu, Reiko, Morita, Tomoko, Iwamatsu, Akihiro, Hachiya, Takahisa, Kurata, Rie, Hirano, Hisashi, Anderson, Philip, Ohno, Shigeo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2009
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682953/
https://ncbi.nlm.nih.gov/pubmed/19417104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1767209
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