Binding of a novel SMG-1–Upf1–eRF1–eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNA containing premature termination codons (PTCs). In mammalian cells, recognition of PTCs requires translation and depends on the presence on the mRNA with the splicing-dependent exon junction complex (EJC). While it is...

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Main Authors: Kashima, Isao, Yamashita, Akio, Izumi, Natsuko, Kataoka, Naoyuki, Morishita, Ryo, Hoshino, Shinichi, Ohno, Mutsuhito, Dreyfuss, Gideon, Ohno, Shigeo
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1361706/
https://ncbi.nlm.nih.gov/pubmed/16452507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1389006
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