Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is a conserved surveillance mechanism that eliminates imperfect mRNAs that contain premature translation termination codons (PTCs) and code for nonfunctional or potentially harmful polypeptides. We show that a novel phosphatidylinositol 3-kinase-related protein kin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Yamashita, Akio, Ohnishi, Tetsuo, Kashima, Isao, Taya, Yoichi, Ohno, Shigeo
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2001
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312771/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11544179/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.913001
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