Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is a conserved surveillance mechanism that eliminates imperfect mRNAs that contain premature translation termination codons (PTCs) and code for nonfunctional or potentially harmful polypeptides. We show that a novel phosphatidylinositol 3-kinase-related protein kin...

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Autores principales: Yamashita, Akio, Ohnishi, Tetsuo, Kashima, Isao, Taya, Yoichi, Ohno, Shigeo
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2001
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC312771/
https://ncbi.nlm.nih.gov/pubmed/11544179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.913001
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