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PRE- AND POSTNATAL EXPOSURE TO KYNURENINE CAUSES COGNITIVE DEFICITS IN ADULTHOOD

Levels of kynurenic acid (KYNA), an endogenous product of tryptophan degradation, are elevated in the brain and cerebrospinal fluid of individuals with schizophrenia (SZ). This increase has been implicated in the cognitive dysfunctions seen in the disease since KYNA is an antagonist of the α7 nicoti...

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Détails bibliographiques
Auteurs principaux: Pocivavsek, Ana, Wu, Hui-Qiu, Elmer, Greg I., Bruno, John P., Schwarcz, Robert
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773083/
https://ncbi.nlm.nih.gov/pubmed/22515201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2012.08064.x
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