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CONTINUOUS KYNURENINE ADMINISTRATION DURING THE PRENATAL PERIOD, BUT NOT DURING ADOLESCENCE, CAUSES LEARNING AND MEMORY DEFICITS IN ADULT RATS
RATIONALE: Cognitive dysfunctions, including deficits in hippocampus-mediated learning and memory, are core features of the psychopathology of schizophrenia (SZ). Increased levels of kynurenic acid (KYNA), an astrocyte-derived tryptophan metabolite and antagonist of α7 nicotinic acetylcholine and N-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4074218/ https://ncbi.nlm.nih.gov/pubmed/24590052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3452-2 |
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