Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK

We previously reported that gliotoxin (GT), the major virulence factor of the mold Aspergillus fumigatus causing invasive aspergillosis (IA) in immunocompromised patients, induces apoptosis in a Bak-dependent manner. The signaling pathway leading to Bak activation and subsequent mitochondrial outer...

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Detalhes bibliográficos
Main Authors: Geissler, A, Haun, F, Frank, D O, Wieland, K, Simon, M M, Idzko, M, Davis, R J, Maurer, U, Borner, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770331/
https://ncbi.nlm.nih.gov/pubmed/23832115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.78
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