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Inhibition of the JNK/Bim Pathway by Hsp70 Prevents Bax Activation in UV-induced Apoptosis

Here we studied the mechanism by which Hsp70 prevents Bax activation during UV-induced apoptosis. UV treatment led to JNK phosphorylation, Bim redistribution and subsequent Bax activation. Bim depletion caused a smaller reduction in apoptosis than that by JNK inhibition, indicating that Bim activati...

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Bibliografiske detaljer
Main Authors: Li, Hui, Liu, Lei, Xing, Da, Chen, Wei R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397246/
https://ncbi.nlm.nih.gov/pubmed/21034742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.10.050
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