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Inhibition of the JNK/Bim Pathway by Hsp70 Prevents Bax Activation in UV-induced Apoptosis
Here we studied the mechanism by which Hsp70 prevents Bax activation during UV-induced apoptosis. UV treatment led to JNK phosphorylation, Bim redistribution and subsequent Bax activation. Bim depletion caused a smaller reduction in apoptosis than that by JNK inhibition, indicating that Bim activati...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3397246/ https://ncbi.nlm.nih.gov/pubmed/21034742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.10.050 |
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