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The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers
There is now strong evidence to show that the presence of the cellular prion protein (PrP(C)) mediates amyloid-β (Aβ) neurotoxicity in Alzheimer's disease (AD). Here, we probe the molecular details of the interaction between PrP(C) and Aβ and discover that substoichiometric amounts of PrP(C), a...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Federation of American Societies for Experimental Biology
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3767752/ https://ncbi.nlm.nih.gov/pubmed/23335053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-222588 |
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