The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers

There is now strong evidence to show that the presence of the cellular prion protein (PrP(C)) mediates amyloid-β (Aβ) neurotoxicity in Alzheimer's disease (AD). Here, we probe the molecular details of the interaction between PrP(C) and Aβ and discover that substoichiometric amounts of PrP(C), a...

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Bibliographic Details
Main Authors: Younan, Nadine D., Sarell, Claire J., Davies, Paul, Brown, David R., Viles, John H.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2013
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767752/
https://ncbi.nlm.nih.gov/pubmed/23335053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-222588
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