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Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death

In Alzheimer disease (AD), amyloid-β (Aβ) oligomer is suggested to play a critical role in imitating neurodegeneration, although its pathogenic mechanism remains to be determined. Recently, the cellular prion protein (PrP(C)) has been reported to be an essential co-factor in mediating the neurotoxic...

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Detalhes bibliográficos
Main Authors: Kudo, Wataru, Lee, Hyun-Pil, Zou, Wen-Quan, Wang, Xinglong, Perry, George, Zhu, Xiongwei, Smith, Mark A., Petersen, Robert B., Lee, Hyoung-gon
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277312/
https://ncbi.nlm.nih.gov/pubmed/22100763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr542
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