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Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease
The cellular prion protein (PrP(C)) can act as a cell-surface receptor for β-amyloid (Aβ) peptide; however, a role for PrP(C) in the pathogenesis of Alzheimer's disease (AD) is contested. Here, we expressed a range of Aβ isoforms and PrP(C) in the Drosophila brain. We found that co-expression o...
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| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6109938/ https://ncbi.nlm.nih.gov/pubmed/29887525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003319 |
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