In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway

BACKGROUND: Tuberculosis (TB) of the central nervous system (CNS) is characterized by extensive tissue inflammation, driven by molecules that cleave extracellular matrix such as matrix metalloproteinase (MMP)-1 and MMP-3. However, relatively little is known about the regulation of these MMPs in the...

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Detalhes bibliográficos
Main Authors: Green, Justin A, Rand, Lucinda, Moores, Rachel, Dholakia, Shruti, Pezas, Theodore, Elkington, Paul T, Friedland, Jon S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765428/
https://ncbi.nlm.nih.gov/pubmed/23978194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-107
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