Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways

Tuberculosis (TB) of the central nervous system (CNS) is a deadly disease characterized by extensive tissue destruction, driven by molecules such as Matrix Metalloproteinase-2 (MMP-2) which targets CNS-specific substrates. In a simplified cellular model of CNS TB, we demonstrated that conditioned me...

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Detalhes bibliográficos
Main Authors: Green, Justin A, Dholakia, Shruti, Janczar, Karolina, Ong, Catherine WM, Moores, Rachel, Fry, Julie, Elkington, Paul T, Roncaroli, Federico, Friedland, Jon S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113956/
https://ncbi.nlm.nih.gov/pubmed/21569377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-46
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