Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are emerging as key mediators of TB immunopathology and their...

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Udgivet i:PLoS Pathog
Main Authors: Ong, Catherine W. M., Elkington, Paul T., Brilha, Sara, Ugarte-Gil, Cesar, Tome-Esteban, Maite T., Tezera, Liku B., Pabisiak, Przemyslaw J., Moores, Rachel C., Sathyamoorthy, Tarangini, Patel, Vimal, Gilman, Robert H., Porter, Joanna C., Friedland, Jon S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440706/
https://ncbi.nlm.nih.gov/pubmed/25996154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004917
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