Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are emerging as key mediators of TB immunopathology and their...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Ong, Catherine W. M., Elkington, Paul T., Brilha, Sara, Ugarte-Gil, Cesar, Tome-Esteban, Maite T., Tezera, Liku B., Pabisiak, Przemyslaw J., Moores, Rachel C., Sathyamoorthy, Tarangini, Patel, Vimal, Gilman, Robert H., Porter, Joanna C., Friedland, Jon S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440706/
https://ncbi.nlm.nih.gov/pubmed/25996154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004917
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