Hypoxia and tissue destruction in pulmonary TB

BACKGROUND: It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix metalloproteinases (MMPs), particularly collagenases such as matrix metalloproteinase-1 (MMP-1). METHODS: We i...

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Опубликовано в: :Thorax
Главные авторы: Belton, Moerida, Brilha, Sara, Manavaki, Roido, Mauri, Francesco, Nijran, Kuldip, Hong, Young T, Patel, Neva H, Dembek, Marcin, Tezera, Liku, Green, Justin, Moores, Rachel, Aigbirhio, Franklin, Al-Nahhas, Adil, Fryer, Tim D, Elkington, Paul T, Friedland, Jon S
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2016
Предметы:
Tuberculosis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136721/
https://ncbi.nlm.nih.gov/pubmed/27245780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2015-207402
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