Hypoxia and tissue destruction in pulmonary TB

BACKGROUND: It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix metalloproteinases (MMPs), particularly collagenases such as matrix metalloproteinase-1 (MMP-1). METHODS: We i...

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Foilsithe in:Thorax
Main Authors: Belton, Moerida, Brilha, Sara, Manavaki, Roido, Mauri, Francesco, Nijran, Kuldip, Hong, Young T, Patel, Neva H, Dembek, Marcin, Tezera, Liku, Green, Justin, Moores, Rachel, Aigbirhio, Franklin, Al-Nahhas, Adil, Fryer, Tim D, Elkington, Paul T, Friedland, Jon S
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMJ Publishing Group 2016
Ábhair:
Tuberculosis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136721/
https://ncbi.nlm.nih.gov/pubmed/27245780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2015-207402
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