Hypoxia and tissue destruction in pulmonary TB

BACKGROUND: It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix metalloproteinases (MMPs), particularly collagenases such as matrix metalloproteinase-1 (MMP-1). METHODS: We i...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Belton, Moerida, Brilha, Sara, Manavaki, Roido, Mauri, Francesco, Nijran, Kuldip, Hong, Young T, Patel, Neva H, Dembek, Marcin, Tezera, Liku, Green, Justin, Moores, Rachel, Aigbirhio, Franklin, Al-Nahhas, Adil, Fryer, Tim D, Elkington, Paul T, Friedland, Jon S
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Tuberculosis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136721/
https://ncbi.nlm.nih.gov/pubmed/27245780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2015-207402
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