Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state

Kainate-selective ionotropic glutamate receptors (iGluRs) fulfil key roles in the CNS, making them the subject of detailed structural and functional analyses. Although they are known to gate a channel pore with high and low ion-permeation rates, it is still not clear how switches between these gatin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Daniels, Bryan A, Andrews, Elizabeth D, Aurousseau, Mark R P, Accardi, Michael V, Bowie, Derek
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2013
Schlagworte:
Neuroscience: Cellular/Molecular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764634/
https://ncbi.nlm.nih.gov/pubmed/23713029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.253666
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