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Kainate receptor pore‐forming and auxiliary subunits regulate channel block by a novel mechanism
KEY POINTS: Kainate receptor heteromerization and auxiliary subunits, Neto1 and Neto2, attenuate polyamine ion‐channel block by facilitating blocker permeation. Relief of polyamine block in GluK2/GluK5 heteromers results from a key proline residue that produces architectural changes in the channel p...
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| Publicado no: | J Physiol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4818602/ https://ncbi.nlm.nih.gov/pubmed/26682513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271690 |
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