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Defining the structural relationship between kainate receptor deactivation and desensitization

Desensitization is an important mechanism that curtails the activity of ligand-gated ion-channels (LGICs). Although the structural basis of desensitization is not fully resolved, it is thought to be governed by the physicochemical properties of the bound ligand. Here, we show the importance of an al...

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Foilsithe in:Nat Struct Mol Biol
Main Authors: Dawe, G. Brent, Musgaard, Maria, Andrews, Elizabeth D., Daniels, Bryan A., Aurousseau, Mark R.P., Biggin, Philip C., Bowie, Derek
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972573/
https://ncbi.nlm.nih.gov/pubmed/23955023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2654
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