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Functional Validation of Heteromeric Kainate Receptor Models

Kainate receptors require the presence of external ions for gating. Most work thus far has been performed on homomeric GluK2 but, in vivo, kainate receptors are likely heterotetramers. Agonists bind to the ligand-binding domain (LBD) which is arranged as a dimer of dimers as exemplified in homomeric...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Paramo, Teresa, Brown, Patricia M.G.E., Musgaard, Maria, Bowie, Derek, Biggin, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700254/
https://ncbi.nlm.nih.gov/pubmed/28935133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.047
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