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Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization

AMPA- and kainate (KA)-selective ionotropic glutamate receptors (iGluRs) respond to agonist by opening (gating), then closing (desensitizing) in quick succession. Gating has been linked to agonist-induced changes within the ligand-binding domain (LBD), and desensitization to rearrangement of a dimer...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Nayeem, Naushaba, Mayans, Olga, Green, Tim
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623771/
https://ncbi.nlm.nih.gov/pubmed/21414913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4771-10.2011
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