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CDR-H3 Diversity is Not Required For Antigen Recognition by Synthetic Antibodies
A synthetic phage-displayed antibody repertoire was constructed with equivalent chemical diversity in the third complementarity-determining regions of the heavy (CDR-H3) and light chains (CDR-L3), which contrasts with natural antibodies in which CDR-H3 is much more diverse than CDR-L3 due to the gen...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3764595/ https://ncbi.nlm.nih.gov/pubmed/23219464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.11.037 |
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