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CDR-H3 Diversity is Not Required For Antigen Recognition by Synthetic Antibodies

A synthetic phage-displayed antibody repertoire was constructed with equivalent chemical diversity in the third complementarity-determining regions of the heavy (CDR-H3) and light chains (CDR-L3), which contrasts with natural antibodies in which CDR-H3 is much more diverse than CDR-L3 due to the gen...

詳細記述

保存先:
書誌詳細
主要な著者: Persson, Helena, Ye, Wei, Wernimont, Amy, Adams, Jarrett J., Koide, Akiko, Koide, Shohei, Lam, Robert, Sidhu, Sachdev S.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764595/
https://ncbi.nlm.nih.gov/pubmed/23219464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.11.037
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