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Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Antigen-binding fragments (Fabs) with synthetic antigen-binding sites were isolated from phage-displayed libraries with restricted complementarity-determining region (CDR) diversity. Libraries were constructed such that solvent-accessible CDR positions were randomized with a degenerate codon that en...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC515084/ https://ncbi.nlm.nih.gov/pubmed/15306681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401786101 |
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