A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins

Targeted therapy development in head and neck squamous cell carcinoma (HNSCC) is challenging given the rarity of activating mutations. Additionally, HNSCC incidence is increasing related to human papillomavirus (HPV). We sought to develop an in vivo model derived from patients reflecting the evolvin...

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Main Authors: Keysar, Stephen B., Astling, David P., Anderson, Ryan T., Vogler, Brian W., Bowles, Daniel W., Morton, J. Jason, Paylor, Jeramiah J., Glogowska, Magdalena J., Le, Phuong N., Eagles-Soukup, Justin R., Kako, Severine L., Takimoto, Sarah M., Sehrt, Daniel B., Umpierrez, Adrian, Pittman, Morgan A., Macfadden, Sarah M., Helber, Ryan M., Peterson, Scott, Hausman, Diana F., Said, Sherif, Leem, Ted H., Goddard, Julie A., Arcaroli, John J., Messersmith, Wells A., Robinson, William A., Hirsch, Fred R., Varella-Garcia, Marileila, Raben, David, Wang, Xiao-Jing, Song, John I., Tan, Aik-Choon, Jimeno, Antonio
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760013/
https://ncbi.nlm.nih.gov/pubmed/23607916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.03.004
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