Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer

The epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab is the only targeted therapy approved for the treatment of head and neck squamous cell carcinoma (HNSCC), but is only effective in a minority of patients. Epithelial-to-mesenchymal transition (EMT) has been implicated...

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Main Authors: Keysar, Stephen B., Le, Phuong N., Anderson, Ryan T., Morton, J. Jason, Bowles, Daniel W., Paylor, Jeramiah J., Vogler, Brian W., Thorburn, Jackie, Fernandez, Pamela, Glogowska, Magdalena J., Takimoto, Sarah M., Sehrt, Daniel B., Gan, Gregory N., Eagles-Soukup, Justin, Serracino, Hilary, Hirsch, Fred R., Lucia, M. Scott, Thorburn, Andrew, Song, John I., Wang, Xiao-Jing, Jimeno, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674118/
https://ncbi.nlm.nih.gov/pubmed/23576557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4047
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