Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer

The epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab is the only targeted therapy approved for the treatment of head and neck squamous cell carcinoma (HNSCC), but is only effective in a minority of patients. Epithelial-to-mesenchymal transition (EMT) has been implicated...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Keysar, Stephen B., Le, Phuong N., Anderson, Ryan T., Morton, J. Jason, Bowles, Daniel W., Paylor, Jeramiah J., Vogler, Brian W., Thorburn, Jackie, Fernandez, Pamela, Glogowska, Magdalena J., Takimoto, Sarah M., Sehrt, Daniel B., Gan, Gregory N., Eagles-Soukup, Justin, Serracino, Hilary, Hirsch, Fred R., Lucia, M. Scott, Thorburn, Andrew, Song, John I., Wang, Xiao-Jing, Jimeno, Antonio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674118/
https://ncbi.nlm.nih.gov/pubmed/23576557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4047
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