Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer

The epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab is the only targeted therapy approved for the treatment of head and neck squamous cell carcinoma (HNSCC), but is only effective in a minority of patients. Epithelial-to-mesenchymal transition (EMT) has been implicated...

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Hauptverfasser: Keysar, Stephen B., Le, Phuong N., Anderson, Ryan T., Morton, J. Jason, Bowles, Daniel W., Paylor, Jeramiah J., Vogler, Brian W., Thorburn, Jackie, Fernandez, Pamela, Glogowska, Magdalena J., Takimoto, Sarah M., Sehrt, Daniel B., Gan, Gregory N., Eagles-Soukup, Justin, Serracino, Hilary, Hirsch, Fred R., Lucia, M. Scott, Thorburn, Andrew, Song, John I., Wang, Xiao-Jing, Jimeno, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674118/
https://ncbi.nlm.nih.gov/pubmed/23576557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4047
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