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Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias

Cytochrome P450 monooxygenases (P450s) have enormous potential in the production of oxychemicals, due to their unparalleled regio- and stereoselectivity. The Bacillus megaterium P450 BM3 enzyme is a key model system, with several mutants (many distant from the active site) reported to alter substrat...

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Auteurs principaux: Butler, Christopher F., Peet, Caroline, Mason, Amy E., Voice, Michael W., Leys, David, Munro, Andrew W.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757202/
https://ncbi.nlm.nih.gov/pubmed/23828198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479717
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