The CRTC1-NEDD9 Signaling Axis Mediates Lung Cancer Progression Caused by LKB1 Loss

Somatic mutation of the tumor suppressor gene LKB1 occurs frequently in lung cancer where it causes tumor progression and metastasis, but the underlying mechanisms remain mainly unknown. Here, we show that the oncogene NEDD9 is an important downstream mediator of lung cancer progression evoked by LK...

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Detalhes bibliográficos
Main Authors: Feng, Yan, Wang, Ye, Wang, Zuoyun, Fang, Zhaoyuan, Li, Fei, Gao, Yijun, Liu, Hongyan, Xiao, Tian, Li, Fuming, Zhou, Yang, Zhai, Qiwei, Liu, Xiaolong, Sun, Yihua, Bardeesy, Nabeel, Wong, Kwok-kin, Chen, Haiquan, Xiong, Zhi-qi, Ji, Hongbin
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755891/
https://ncbi.nlm.nih.gov/pubmed/23074285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1909
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