Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma

Lineage transition in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) of non-small cell lung cancer, as implicated by clinical observation of mixed ADC and SCC pathologies in adenosquamous cell carcinoma, remains a fundamental yet unsolved question. Here we provide in vivo evidence showing th...

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Main Authors: Han, Xiangkun, Li, Fuming, Fang, Zhaoyuan, Gao, Yijun, Li, Fei, Fang, Rong, Yao, Shun, Sun, Yihua, Li, Li, Zhang, Wenjing, Ma, Huimin, Xiao, Qian, Ge, Gaoxiang, Fang, Jing, Wang, Hongda, Zhang, Lei, Wong, Kwok-kin, Chen, Haiquan, Hou, Yingyong, Ji, Hongbin
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929783/
https://ncbi.nlm.nih.gov/pubmed/24531128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4261
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