LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

LKB1 loss-of-function mutations, observed in ∼30% of human lung adenocarcinomas, contribute significantly to lung cancer malignancy progression. We show that lysyl oxidase (LOX), negatively regulated by LKB1 through mTOR-HIF-1α signaling axis, mediates lung cancer progression. Inhibition of LOX acti...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Gao, Yijun, Xiao, Qian, Ma, HuiMin, Li, Li, Liu, Jun, Feng, Yan, Fang, Zhaoyuan, Wu, Jing, Han, Xiangkun, Zhang, Junhua, Sun, Yihua, Wu, Gongwei, Padera, Robert, Chen, Haiquan, Wong, Kwok-kin, Ge, Gaoxiang, Ji, Hongbin
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973865/
https://ncbi.nlm.nih.gov/pubmed/20956321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004952107
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