LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response

LKB1 regulates both cell growth and energy metabolism. It remains unclear how LKB1 inactivation coordinates tumor progression with metabolic adaptation in non-small cell lung cancer (NSCLC). Here in Kras(G12D);Lkb1(lox/lox) (KL) mouse model, we reveal differential reactive oxygen species (ROS) level...

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Bibliographic Details
Published in:Cancer Cell
Main Authors: Li, Fuming, Han, Xiangkun, Li, Fei, Wang, Rui, Wang, Hui, Gao, Yijun, Wang, Xujun, Fang, Zhaoyuan, Zhang, Wenjing, Yao, Shun, Tong, Xinyuan, Wang, Yuetong, Feng, Yan, Sun, Yihua, Li, Yuan, Wong, Kwok-Kin, Zhai, Qiwei, Chen, Haiquan, Ji, Hongbin
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746728/
https://ncbi.nlm.nih.gov/pubmed/25936644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.04.001
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