Nanog maintains stemness of Lkb1‐deficient lung adenocarcinoma and prevents gastric differentiation

Growing evidence supports that LKB1‐deficient KRAS‐driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity that promotes lineage conversion and drug resistance. Here we find that murine lung tumors from the Kras(LSL‐G12D/+); Lkb1(flox/flox) (KL) model show st...

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Publicado en:EMBO Mol Med
Autores principales: Tong, Xinyuan, Chen, Yueqing, Zhu, Xinsheng, Ye, Yi, Xue, Yun, Wang, Rui, Gao, Yijun, Zhang, Wenjing, Gao, Weiqiang, Xiao, Lei, Chen, Haiquan, Zhang, Peng, Ji, Hongbin
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933951/
https://ncbi.nlm.nih.gov/pubmed/33439550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012627
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