Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3

Brown adipose tissue (BAT) dissipates energy through Ucp1-mediated uncoupled respiration and its activation may represent a therapeutic strategy to combat obesity. Here we show that Lkb1 controls BAT expansion and UCP1 expression in mice. We generate adipocyte-specific Lkb1 knockout mice and show th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Shan, Tizhong, Xiong, Yan, Zhang, Pengpeng, Li, Zhiguo, Jiang, Qingyang, Bi, Pengpeng, Yue, Feng, Yang, Gongshe, Wang, Yizhen, Liu, Xiaoqi, Kuang, Shihuan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974456/
https://ncbi.nlm.nih.gov/pubmed/27461402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12205
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