Modification of Triclosan Scaffold in Search of Improved Inhibitors for Enoyl-Acyl Carrier Protein (ACP) Reductase in Toxoplasma gondii

Through our focused effort to discover new and effective agents against toxoplasmosis, a structure-based drug design approach was utilized to develop a series of potent inhibitors of the enoyl-acyl carrier protein (ACP) reductase (ENR) enzyme in Toxoplasma gondii (TgENR). Modifications to positions...

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Autores principales: Stec, Jozef, Fomovska, Alina, Afanador, Gustavo A., Muench, Stephen P., Zhou, Ying, Lai, Bo-Shiun, Bissati, Kamal El, Hickman, Mark R., Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Sommervile, Caroline, Woods, Stuart, Roberts, Craig W., Rice, David, Prigge, Sean T., McLeod, Rima, Kozikowski, Alan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755765/
https://ncbi.nlm.nih.gov/pubmed/23776166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300050
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