Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum

Triclosan, a known antibacterial, acts by inhibiting enoyl-ACP (acyl-carrier protein) reductase (ENR), a key enzyme of the type II fatty acid synthesis (FAS) system. Plasmodium falciparum, the human malaria-causing parasite, harbours the type II FAS; in contrast, its human host utilizes type I FAS....

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Bibliographic Details
Main Authors: Kapoor, Mili, Gopalakrishnapai, Jayashree, Surolia, Namita, Surolia, Avadhesha
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133883/
https://ncbi.nlm.nih.gov/pubmed/15139852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040302
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