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Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase
Enoyl-acyl carrier protein reductase (ENR), a critical enzyme in type II fatty acid biosynthesis, is a promising target for drug discovery against hepatocyte-stage Plasmodium falciparum. In order to identify PfENR-specific inhibitors, we docked 70 FDA-approved, bioactive, and/or natural product smal...
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| Publicado no: | Bioorg Med Chem |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4807855/ https://ncbi.nlm.nih.gov/pubmed/25284249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.002 |
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