Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase

Enoyl-acyl carrier protein reductase (ENR), a critical enzyme in type II fatty acid biosynthesis, is a promising target for drug discovery against hepatocyte-stage Plasmodium falciparum. In order to identify PfENR-specific inhibitors, we docked 70 FDA-approved, bioactive, and/or natural product smal...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Tallorin, Lorillee C., Durrant, Jacob D., Nguyen, Quynh G., McCammon, J. Andrew, Burkart, Michael D.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807855/
https://ncbi.nlm.nih.gov/pubmed/25284249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.002
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki