Myxomavirus-Derived Serpin Prolongs Survival and Reduces Inflammation and Hemorrhage in an Unrelated Lethal Mouse Viral Infection

Lethal viral infections produce widespread inflammation with vascular leak, clotting, and bleeding (disseminated intravascular coagulation [DIC]), organ failure, and high mortality. Serine proteases in clot-forming (thrombotic) and clot-dissolving (thrombolytic) cascades are activated by an inflamma...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Chen, Hao, Zheng, Donghang, Abbott, Jeff, Liu, Liying, Bartee, Mee Y., Long, Maureen, Davids, Jennifer, Williams, Jennifer, Feldmann, Heinz, Strong, James, Grau, Katrina R., Tibbetts, Scott, Macaulay, Colin, McFadden, Grant, Thoburn, Robert, Lomas, David A., Spinale, Francis G., Virgin, Herbert W., Lucas, Alexandra
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2013
Θέματα:
Antiviral Agents
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754305/
https://ncbi.nlm.nih.gov/pubmed/23774438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02594-12
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