Myxomavirus-Derived Serpin Prolongs Survival and Reduces Inflammation and Hemorrhage in an Unrelated Lethal Mouse Viral Infection

Lethal viral infections produce widespread inflammation with vascular leak, clotting, and bleeding (disseminated intravascular coagulation [DIC]), organ failure, and high mortality. Serine proteases in clot-forming (thrombotic) and clot-dissolving (thrombolytic) cascades are activated by an inflamma...

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Библиографические подробности
Главные авторы: Chen, Hao, Zheng, Donghang, Abbott, Jeff, Liu, Liying, Bartee, Mee Y., Long, Maureen, Davids, Jennifer, Williams, Jennifer, Feldmann, Heinz, Strong, James, Grau, Katrina R., Tibbetts, Scott, Macaulay, Colin, McFadden, Grant, Thoburn, Robert, Lomas, David A., Spinale, Francis G., Virgin, Herbert W., Lucas, Alexandra
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2013
Предметы:
Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754305/
https://ncbi.nlm.nih.gov/pubmed/23774438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02594-12
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