Myxomavirus-Derived Serpin Prolongs Survival and Reduces Inflammation and Hemorrhage in an Unrelated Lethal Mouse Viral Infection

Lethal viral infections produce widespread inflammation with vascular leak, clotting, and bleeding (disseminated intravascular coagulation [DIC]), organ failure, and high mortality. Serine proteases in clot-forming (thrombotic) and clot-dissolving (thrombolytic) cascades are activated by an inflamma...

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Bibliografiset tiedot
Päätekijät: Chen, Hao, Zheng, Donghang, Abbott, Jeff, Liu, Liying, Bartee, Mee Y., Long, Maureen, Davids, Jennifer, Williams, Jennifer, Feldmann, Heinz, Strong, James, Grau, Katrina R., Tibbetts, Scott, Macaulay, Colin, McFadden, Grant, Thoburn, Robert, Lomas, David A., Spinale, Francis G., Virgin, Herbert W., Lucas, Alexandra
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2013
Aiheet:
Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754305/
https://ncbi.nlm.nih.gov/pubmed/23774438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02594-12
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