Myxomavirus-Derived Serpin Prolongs Survival and Reduces Inflammation and Hemorrhage in an Unrelated Lethal Mouse Viral Infection

Lethal viral infections produce widespread inflammation with vascular leak, clotting, and bleeding (disseminated intravascular coagulation [DIC]), organ failure, and high mortality. Serine proteases in clot-forming (thrombotic) and clot-dissolving (thrombolytic) cascades are activated by an inflamma...

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Hlavní autoři: Chen, Hao, Zheng, Donghang, Abbott, Jeff, Liu, Liying, Bartee, Mee Y., Long, Maureen, Davids, Jennifer, Williams, Jennifer, Feldmann, Heinz, Strong, James, Grau, Katrina R., Tibbetts, Scott, Macaulay, Colin, McFadden, Grant, Thoburn, Robert, Lomas, David A., Spinale, Francis G., Virgin, Herbert W., Lucas, Alexandra
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754305/
https://ncbi.nlm.nih.gov/pubmed/23774438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02594-12
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