Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP)()

Processing of β-amyloid precursor protein (APP) by β- and γ-secretases in neurons produces amyloid-β (Aβ), whose excess accumulation leads to Alzheimer’s disease (AD). Knowledge on subcellular trafficking pathways of APP and its fragments is important for the understanding of AD pathogenesis. We des...

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Bibliographic Details
Main Authors: Coughlan, Kathleen, Huang, Xiangping, He, Xiangyuan, Chung, Charlotte H.Y., Li, Guangpu, Tang, Jordan
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753662/
https://ncbi.nlm.nih.gov/pubmed/23517619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.03.003
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