Apolipoprotein Receptor 2 and X11α/β Mediate Apolipoprotein E-Induced Endocytosis of Amyloid-β Precursor Protein and β-Secretase, Leading to Amyloid-β Production

The homeostasis of amyloid-β (Aβ) in the brain is critical to the pathogenesis of Alzheimer's disease (AD). Aβ is a fragment of amyloid-β precursor protein (APP) generated in neurons by two proteases, β- and γ-secretases. APP and β-secretase, both present on cell surface, are endocytosed into e...

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Bibliographic Details
Published in:J Neurosci
Main Authors: He, Xiangyuan, Cooley, Kathleen, Chung, Charlotte H. Y., Dashti, Nassrin, Tang, Jordan
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672528/
https://ncbi.nlm.nih.gov/pubmed/17428983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3993-06.2007
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