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Apolipoprotein Receptor 2 and X11α/β Mediate Apolipoprotein E-Induced Endocytosis of Amyloid-β Precursor Protein and β-Secretase, Leading to Amyloid-β Production
The homeostasis of amyloid-β (Aβ) in the brain is critical to the pathogenesis of Alzheimer's disease (AD). Aβ is a fragment of amyloid-β precursor protein (APP) generated in neurons by two proteases, β- and γ-secretases. APP and β-secretase, both present on cell surface, are endocytosed into e...
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| Publicado en: | J Neurosci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Society for Neuroscience
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6672528/ https://ncbi.nlm.nih.gov/pubmed/17428983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3993-06.2007 |
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