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Amyloid Precursor Protein (APP) and GABAergic Neurotransmission
The amyloid precursor protein (APP) is the parent polypeptide from which amyloid-beta (Aβ) peptides, key etiological agents of Alzheimer’s disease (AD), are generated by sequential proteolytic processing involving β- and γ-secretases. APP mutations underlie familial, early-onset AD, and the involvem...
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| Udgivet i: | Cells |
|---|---|
| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6627941/ https://ncbi.nlm.nih.gov/pubmed/31174368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8060550 |
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