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Amyloid precursor protein (APP) regulates synaptic structure and function
The amyloid precursor protein (APP) plays a critical role in Alzheimer’s disease (AD) pathogenesis. APP is proteolytically cleaved by β- and γ-secretases to generate the amyloid β-protein (Aβ), the core protein component of senile plaques in AD. It is also cleaved by α-secretase to release the large...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538857/ https://ncbi.nlm.nih.gov/pubmed/22884903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2012.07.009 |
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