Amyloid precursor protein (APP) regulates synaptic structure and function

The amyloid precursor protein (APP) plays a critical role in Alzheimer’s disease (AD) pathogenesis. APP is proteolytically cleaved by β- and γ-secretases to generate the amyloid β-protein (Aβ), the core protein component of senile plaques in AD. It is also cleaved by α-secretase to release the large...

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Detalhes bibliográficos
Main Authors: Tyan, Sheue-Houy, Shih, Ann Yu-Jung, Walsh, Jessica J., Murayama, Hiroko, Sarsoza, Floyd, Ku, Lawrence, Eggert, Simone, Hof, Patrick R., Koo, Edward H., Dickstein, Dara L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538857/
https://ncbi.nlm.nih.gov/pubmed/22884903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2012.07.009
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