Amyloid precursor protein (APP) regulates synaptic structure and function

The amyloid precursor protein (APP) plays a critical role in Alzheimer’s disease (AD) pathogenesis. APP is proteolytically cleaved by β- and γ-secretases to generate the amyloid β-protein (Aβ), the core protein component of senile plaques in AD. It is also cleaved by α-secretase to release the large...

Full description

Saved in:
Bibliographic Details
Main Authors: Tyan, Sheue-Houy, Shih, Ann Yu-Jung, Walsh, Jessica J., Murayama, Hiroko, Sarsoza, Floyd, Ku, Lawrence, Eggert, Simone, Hof, Patrick R., Koo, Edward H., Dickstein, Dara L.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538857/
https://ncbi.nlm.nih.gov/pubmed/22884903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2012.07.009
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items