Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease

Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer’s disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β pr...

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Vydáno v:Cell Rep
Hlavní autoři: Park, Goonho, Nhan, Hoang S., Tyan, Sheue-Houy, Kawakatsu, Yusuke, Zhang, Carolyn, Navarro, Mario, Koo, Edward H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375398/
https://ncbi.nlm.nih.gov/pubmed/32610140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107839
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