A role for APP in Wnt signalling links synapse loss with β-amyloid production

In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability, while non-canonical (Wnt-PCP) signalling favours synaps...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Elliott, Christina, Rojo, Ana I., Ribe, Elena, Broadstock, Martin, Xia, Weiming, Morin, Peter, Semenov, Mikhail, Baillie, George, Cuadrado, Antonio, Al-Shawi, Raya, Ballard, Clive G., Simons, Paul, Killick, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145937/
https://ncbi.nlm.nih.gov/pubmed/30232325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0231-6
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