Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil

INTRODUCTION: Synapse loss is the structural correlate of the cognitive decline indicative of dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ) peptides aggregate to form senile plaques but as soluble peptides are toxic to synapses. We previously demonstrated that Aβ indu...

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Udgivet i:Alzheimers Dement
Main Authors: Sellers, Katherine J., Elliott, Christina, Jackson, Joshua, Ghosh, Anshua, Ribe, Elena, Rojo, Ana I., Jarosz-Griffiths, Heledd H., Watson, Iain A., Xia, Weiming, Semenov, Mikhail, Morin, Peter, Hooper, Nigel M., Porter, Rod, Preston, Jane, Al-Shawi, Raya, Baillie, George, Lovestone, Simon, Cuadrado, Antonio, Harte, Michael, Simons, Paul, Srivastava, Deepak P., Killick, Richard
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier, Inc 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869054/
https://ncbi.nlm.nih.gov/pubmed/29055813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2017.09.008
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